Victor Boniface put in a disciplined and positive shift as his Royale Union Saint-Gilloise did their title dreams a world of good with a commanding [3-0] victory over Tolu Arokodare's KRC Genk.
Antwerp remain ahead of all other title challengers, though, after Alhassan Yusuf came off the bench to help them seal a vital [3 - 2] victory over Club Brugge.
In the MLS, Chinonso Offor picked up a well-deserved man-of-the-match award after scoring the second goal in Montréal's [2 - 0] triumph over Toronto.
Super Eagles striker, Sunusi Ibrahim replaced Offor in the 83rd minute but his search for his first league goal of the season continues.
In the FNL, Abdoullahi Tanko scored the first hat-trick of his career to propel Varnsdorf to a thrilling [5 - 3] win at home to Táborsko.
In the English Premier League, Frank Onyeka featured for the last 20 minutes of Brentford's crucial [2-0] victory over West Ham at the Gtech Community Stadium in Brentford, Middlesex.
At Goodison Park , Alex Iwobi ended up on the losing side as Everton crumbled to a [0-3] defeat against Manchester City.
Bonke Innocent delivered a solid display in midfield to help Lorient battle to a [1-1] draw at Montpellier.
The game between Toulouse and Nantes also ended in a goalless draw, with Moses Simon impressing for the relegation-battling visitors.
Victor Osimhen was denied a penalty call as champions Napoli fell to a surprise [0-2] loss away to Monza in the Italian Serie A.
Jos-born Mathias Oyewusi scored the crucial goal that helped Zalgiris soar to a fine [2 - 1] victory over Kauno Zalgiris.
Abraham Marcus bagged his ninth league goal of the campaign to lift Porto II to a deserved [3 - 1] victory over Academico Viseu.
In a Spanish Women's First Division clash at the Estadio La Palmera in Tenerife, Gift Monday was the best player on the pitch as she bagged an assist and a goal to inspire Granadilla Tenerife to a convincing [3-1] win over Toni Payne's Seville.
Anam Mary Imo made it five goals in her last four games as Piteå overcame Hammarby's resistance with a [2-1] triumph.
In the USL Championship, Tani Oluwaseyi was the standout performer as he scored twice and set up another two goals as San Antonio ran out [0-7] winners on the home ground of Charleston Battery. Samuel Adediran was also on target for the winning team.
Ade Oguns scored for the third consecutive game to lift Caracas to a hard-fought [1 - 1] draw at home to Deportivo La Guaira.